The challenge proposed by the HP-NANOBIO project is based on the development of a treatment system for antibiotics removal based on the use of nanoparticles and atomic clusters as high-performance photocatalysts combined with enzymes immobilized in nanoparticles to advance in the design of technologies that are environmentally friendly and economically sustainable. The cascade process combining photochemistry and biocatalysis with magnetically separable nanoparticles has not been addressed before.